The Creamiest Cheesy Chicken, Spinach, and Artichoke Lasagna Recipe

Crafting a mouthwatering cheesy chicken, spinach, and artichoke lasagna brings comfort right to your dinner table.

Mediterranean flavors dance through layers of delicate pasta and rich ingredients.

Creamy textures blend perfectly with tender chicken and earthy spinach.

Artichoke hearts add unexpected complexity to this classic dish.

Fresh herbs and melted cheese create an irresistible combination that feels like a warm embrace.

Weeknight meals never looked so inviting or tasted so incredible.

You’ll want to savor every single bite of this delightful lasagna.

Why Cheesy Chicken, Spinach, And Artichoke Lasagna Is A Must-Try

• Savor Simplified Cooking: Packed with flavor and minimal fuss, this chicken lasagna delivers deliciousness without complicated steps.
• Customize with Ease: Swap ingredients like switching spinach for kale or adding different herbs to match your taste preferences and pantry availability.
• Crowd-Pleasing Comfort: Perfect for family dinners, potlucks, or feeding a hungry group with its hearty layers of protein, vegetables, and creamy cheese.
• Make-Ahead Magic: Assemble the lasagna in advance, refrigerate, and bake when ready, making meal planning and preparation stress-free for busy home cooks.

What You’ll Need For Cheesy Chicken, Spinach, And Artichoke Lasagna

• Chicken Breasts: Tender meat providing protein and creating a hearty foundation for the lasagna.

• Lasagna Noodles: Classic pasta sheets that create layers and structure in the dish.

• Cream Cheese: Adds rich, creamy texture to the sauce.
• Mozzarella Cheese, Parmesan Cheese: Provide melty, savory cheese layers with classic Italian flavor.
• Heavy Cream: Enhances sauce smoothness and richness.

• Artichoke Hearts: Offer a unique, slightly tangy flavor and tender texture.
• Spinach: Adds nutritional value and vibrant green color to the lasagna.
• Garlic: Provides aromatic depth and robust flavor to the dish.

• Olive Oil: Helps with sautéing and adds subtle flavor.
• Chicken Broth: Creates a flavorful base for layering and prevents dryness.

• Salt, Pepper: Basic seasonings that enhance overall taste of the chicken and dish.

How To Bake Cheesy Chicken, Spinach, And Artichoke Lasagna

Step 1: Warm Up the Oven

Set your oven to 375°F and lightly grease a 9×13-inch baking dish with olive oil to prevent sticking.

Step 2: Cook Pasta Noodles

Boil lasagna noodles in salted water until they reach al dente texture. Drain and spread on a clean kitchen towel to keep them from clumping together.

Step 3: Season and Cook Chicken

• Salt
• Pepper

Cut chicken breasts into bite-sized cubes and season with salt and pepper. Sauté in a large skillet with olive oil over medium-high heat until golden brown and fully cooked, about 6-8 minutes.

Step 4: Prepare Vegetable Base

• Chopped artichoke hearts
• Spinach

Cook until spinach wilts and releases its moisture.

Step 5: Create Creamy Cheese Mixture

• Cream cheese
• Heavy cream
• Half of mozzarella cheese
• Half of parmesan cheese

Mix until smooth and creamy.

Step 6: Build Lasagna Layers

• Pasta noodles
• Cooked chicken
• Vegetable mixture
• Cheese sauce

Repeat until all ingredients are used, ensuring the top layer is completely covered with remaining cheese.

Step 7: Bake to Perfection

Cover the dish with aluminum foil and bake for 30 minutes. Remove foil and continue baking for an additional 15 minutes until cheese turns golden and bubbly.

Step 8: Rest and Serve

Allow lasagna to rest for 10 minutes before serving. This helps the layers set and flavors meld together, creating a delicious final dish.

Helpful Tips For Cheesy Chicken, Spinach, And Artichoke Lasagna

• Prevent Noodle Sticking: Spread cooked lasagna noodles on a clean kitchen towel to stop them from clumping together and tearing during layering.
• Enhance Flavor Depth: Sauté garlic in the same skillet used for chicken to capture and transfer delicious browned bits and maximize flavor complexity.
• Master Even Cooking: Dice chicken into uniform bite-sized cubes to ensure consistent golden browning and prevent undercooked or dry sections.
• Achieve Perfect Cheese Texture: Blend cream cheese with heavy cream until smooth to create a creamy, luxurious sauce that coats ingredients evenly and prevents graininess.
• Rest for Better Slicing: Allow lasagna to sit for 10 minutes after baking so layers can set, making cutting and serving cleaner and more structured.

Tasty Options For Cheesy Chicken, Spinach, And Artichoke Lasagna

• Vegetarian Mediterranean Lasagna: Replace chicken with roasted eggplant and zucchini, using plant-based ricotta for a hearty meat-free version.
• Gluten-Free Spinach Artichoke Lasagna: Swap traditional lasagna noodles with gluten-free alternatives like zucchini sheets or rice noodles, maintaining the original flavor profile.
• Low-Carb Keto Chicken Bake: Eliminate pasta entirely, using thinly sliced zucchini or cauliflower layers instead, and increase fat content with extra cheese and cream.
• Greek-Inspired Chicken Lasagna: Incorporate feta cheese, oregano, and kalamata olives to give the dish a Mediterranean flavor transformation.

What Goes With Cheesy Chicken, Spinach, And Artichoke Lasagna

• Refresh with Crisp White Wine: Pair this creamy chicken artichoke lasagna with a chilled Pinot Grigio, whose light acidity cuts through the rich cheese and complements the delicate chicken flavor.
• Create a Fresh Salad Side: Toss a zesty arugula salad with lemon vinaigrette and shaved parmesan to balance the lasagna's richness and add a bright, peppery contrast to each bite.
• Complement with Herbal Garnish: Sprinkle fresh chopped basil or parsley over the lasagna to enhance the artichoke and spinach notes, adding a vibrant, aromatic layer to the dish.

How To Store Cheesy Chicken, Spinach, And Artichoke Lasagna Properly

• Store leftover lasagna in an airtight container within 2 hours of cooking. Seal tightly to prevent moisture loss and prevent bacteria growth. Keeps fresh for 3-4 days in the refrigerator.
• Wrap individual portions or entire lasagna in plastic wrap, then aluminum foil. Label with date and contents. Freeze up to 3 months. Frozen lasagna maintains best quality when used within 1-2 months.
• Cut desired portion, place on microwave-safe plate. Cover with damp paper towel to retain moisture. Heat at 50% power for 2-3 minutes, checking temperature halfway through. Stir or rotate for even heating.
• Preheat oven to 350°F.

FAQs About Cheesy Chicken, Spinach, And Artichoke Lasagna

• Is this lasagna gluten-free?

No, traditional lasagna noodles contain wheat. To make it gluten-free, use gluten-free lasagna noodles or substitute with zucchini slices.

• Can I use frozen spinach instead of fresh?

Yes, thaw and drain frozen spinach completely before adding to the skillet to prevent excess moisture in the lasagna.

• What type of chicken works best for this recipe?

Boneless, skinless chicken breasts are ideal because they’re lean, cook quickly, and absorb seasonings well. Chicken thighs can also work for more flavor.

• How do I prevent the lasagna from becoming watery?

Ensure spinach is well-drained, pat chicken dry before cooking, and avoid adding extra liquid to maintain a rich, creamy texture.

Cheesy Chicken, Spinach, And Artichoke Lasagna Recipe

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4.9 from 24 reviews

• Total Time: 1 hour 23 minutes
• Yield: 8 1x

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Description

Creamy layers of cheesy chicken, spinach, and artichoke lasagna promise a comforting Mediterranean-inspired feast. Melted cheese, tender chicken, and earthy artichokes create a luxurious pasta experience you’ll crave again and again.

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Ingredients

Scale 1x2x3x

Pasta:

• 12 lasagna noodles (sheets)
• 1 package/454 g lasagna noodles (fresh or dried)

Protein and Vegetables:

• 2 lbs/907 g boneless, skinless chicken breast
• 4 cups/340 g fresh spinach
• 2 cans/425 g artichoke hearts

Dairy and Seasoning:

• 3 cups/680 g cream cheese
• 2 cups/227 g mozzarella cheese
• 1 cup/227 g parmesan cheese
• 1 cup/240 ml heavy cream
• 4 cloves garlic
• 1 tsp salt
• 1/2 tsp black pepper
• 2 tbsp olive oil
• 1/4 cup/60 ml chicken broth

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Instructions

1. Preheat the oven to 375°F and prepare a 9×13-inch baking dish with a light olive oil coating.
2. Cook lasagna noodles in salted boiling water until al dente, then drain and set aside on a clean kitchen towel to prevent sticking.
3. Season chicken breasts with salt and pepper, then dice into bite-sized cubes for even cooking.
4. Heat olive oil in a large skillet over medium-high heat and sauté chicken until golden and cooked through, approximately 6-8 minutes.
5. Remove chicken from skillet and set aside, then in the same pan, sauté minced garlic until fragrant.
6. Add chopped artichoke hearts and spinach to the skillet, cooking until spinach wilts and releases moisture.
7. In a mixing bowl, blend cream cheese, heavy cream, and half of the mozzarella and parmesan cheeses until smooth and creamy.
8. Layer the lasagna by spreading a thin chicken broth base in the baking dish, then alternating noodles, chicken, vegetable mixture, and cheese sauce.
9. Repeat layering until all ingredients are used, ensuring the top layer is covered with remaining cheese.
10. Cover the dish with aluminum foil and bake for 30 minutes.
11. Remove foil and continue baking for an additional 15 minutes until cheese is golden and bubbly.
12. Let the lasagna rest for 10 minutes before serving to allow layers to set and flavors to meld.

Notes

• Swap protein options by using tofu, shredded turkey, or white fish for varied dietary preferences and exciting flavor combinations.
• Reduce carbohydrate content by replacing traditional lasagna noodles with zucchini strips or low-carb cauliflower sheets for a lighter meal.
• Enhance nutritional value by incorporating additional vegetables like roasted bell peppers, mushrooms, or kale to boost vitamin and mineral content.
• Create a dairy-free version using cashew cream, nutritional yeast, and plant-based cheese alternatives for lactose-intolerant or vegan guests.

• Prep Time: 20 minutes
• Cook Time: 53 minutes
• Category: Lunch, Dinner
• Method: Baking
• Cuisine: Italian-American

Nutrition

• Serving Size: 8
• Calories: 663
• Sugar: 3 g
• Sodium: 1092 mg
• Fat: 38 g
• Saturated Fat: 18 g
• Unsaturated Fat: 16 g
• Trans Fat: 0 g
• Carbohydrates: 42 g
• Fiber: 2 g
• Protein: 46 g
• Cholesterol: 145 mg